… changes in size and type of MC, after a single intravenous infusion of 5 mg zoledronic acid
(ZA) or placebo, among chronic LBP patients with … the MRI changes correlate with symptoms. …

… We analyzed the MRIs for type and volume of each MC from sagittal images at a clinical
workstation (Neaview Radiology, version 2.23, Neagen Corporation, Oulu, Finland) [23]. MC …

… effect of zoledronic acid (ZA) and denosumab on low back pain (LBP) and Modic change (…
Adults aged ≥40 years with significant LBP for at least 6 months duration and MC (type 1, 2, …

… The patients were well informed of possible adverse effects; this may have contributed to a
large amount of reports of acute phase reaction symptoms. Some of the main determinants of …

… Zoledronic acid is a potent bisphosphonate that has … or less volume/extent of MC affecting
the vertebral body/subchondral bone region. In further support, a recent study among patients …

… this study was to evaluate the effect of zoledronic acid (ZA) and denosumab on low 25 … effect
of zoledronic acid on type and volume of Modic changes among patients with low back pain. …

… zoledronic acid had a positive efficacy in the treatment of LBP with MC, with mild to moderate
side effects… , renal function must be monitored during zoledronic acid treatment. Hence, we …

… The percentage of patients with grade 1 Modic changes (… volume was observed in the
antibiotic group, where changes … Should zoledronic acid be used as a conservative treatment …

… in patients with low back pain, and Modic changes undergoing … However, in terms of quantity
and quality data, it was less … The zoledronic acid effect was confirmed in decreasing the …

… Lumbar Modic change (MC) can serve as a diagnostic marker as well as an independent
source of chronic low back pain (… Type or volume of MC was not associated with biomarker …